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The study identified a regulatory axis (VDAC3/DHODH) that enhances GSH-mediated ferroptosis resistance, demonstrating significant cardioprotective outcomes in vivo (Wang J

By boosting -hydroxybutyrate (BHB) levels, the ketogenic diet was able to: Reduce mitochondrial damage and oxidative stress Enhance TOMM20 expression, indicating better mitochondrial integrity Decrease neuronal apoptosis by balancing Bax/Bcl-2 expression Improve functional motor recovery This study reinforces the view that , it represents a mitochondrial therapy capable of modulating cellular resilience and recovery after neurotrauma

Stability and solubility of trans-resveratrol are strongly influenced by pH and temperature

Another mechanism leading to methotrexate resistance is elevated production of DHFR resulting from an increase in the number of copies of the DHFR gene (gene amplification) (see Fig