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de Bari L, Scir A, Minnelli C, Cianfruglia L, Kalapos MP, Armeni T: Interplay among Oxidative Stress, Methylglyoxal Pathway and S-Glutathionylation

It has been investigated that TMAO reduces the expression of CYP7A1 and CYP27A1, two key enzymes necessary for the synthesis of BAs, and various BA transport proteins, decreases BA biosynthesis, inhibits the reverse cholesterol transport (RCT) pathway, and affects BA metabolism and cholesterol homeostasis in the hepatic-intestinal tract (Wang et al., 2011)

Cell 173, 554567

The phagocytic capacity of macrophages toward ferroptotic tumor cells demonstrates anti-tumor activity, with various immune-stimulatory signals released by ferroptotic tumor cells enhancing phagocytic efficiency ( 6 Iron metabolisms influence on macrophage polarization Macrophages store iron through FT binding, with iron-related gene expression profiles varying across polarization stages

Here we have found a potent antioxidant moiety Scopoletin (Sp), a common derivative in most of the nootropic herbs, with robust neuroprotective ability