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Liver-specific Chac1 and GFP overexpression mice were generated through retro-orbital injections of AAV8 (4 10 10 viral particles per mouse) expressing Chac1 or GFP controlled by human TBG promoter

Metabolites such as coumarin , L-leucine , pyroglutamic acid , and L-proline , which showed higher relative abundance at baseline, demonstrated reduced levels following GF-MKD

Changes in lipid metabolism are closely associated with disruptions in homeostasis and the development of neurodegenerative diseases

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The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2