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Although the development of the IVC environment is relatively complete, embryos produced in vitro have less developmental potential than embryos developing in vivo because they lack the protective maternal endocrine environment provided to embryos developing in vivo 19,32

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In PTC and anaplastic thyroid carcinoma, somatic KEAP1 and NFE2L2 mutations activating the Nrf2 pathway were discovered (128, 129)

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Intestinal enteroendocrine lineage cells possess homeostatic and injury-inducible stem cell activity