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10.1016/j.virol.2023.109903 Virology 120 LegendreD.FastrezJ

Cytomegalovirus in haematological tumours

Interestingly, iron ions serve as cofactors for PHD enzymes, which hydroxylate and target HIF-1 for degradation (Lawson et al., 2024

In parallel, iron-handling disturbances (such as labile iron accumulation and ferritinophagy-mediated iron release) initiate a pre-ferroptotic state, lowering the threshold for ferroptotic execution upon inflammatory or mechanical insults (13,14)