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The serious adverse events documented in HPS2-THRIVE (increased diabetes, infections, gastrointestinal problems, bleeding, and musculoskeletal complications) make high-dose nicotinic acid a risk that is difficult to justify without a clear clinical indication

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j) ELECTRONIC COMMUNICATIONS PERMITTED: Electronic communications are permitted to both Parties under this Agreement, including e-mail or fax

Concurrent liver dysfunction, by impairing copper excretion, further increases the risk of accumulation and adverse cardiovascular events [242, 249]

doi:10.1186/s13041-014-0049-y