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56 Disruption in cell membrane permeability results in extensive dyshomeostasis (imbalance of homeostasis)

The gating strategy is described in Supplemental Figure 1

Bioactive phytoconstituents in foods and MPs, such as alkaloids, peptides, flavonoids, anthocyanins, phenolic acids, and polyphenols, are recognized for their preventive and therapeutic benefits for CV health

The degree of this downregulation correlates positively with the severity of cartilage degeneration, being most pronounced in advanced lesions characterized by surface fibrillation and severe proteoglycan loss (Miao et al., 2022

These disease-specific mechanistic insights emphasize the importance of targeting discrete mTOR-PTM-cell death axes for precision therapy in cardiovascular diseases