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You may need methylcobalamin if you are deficient in methyl-groups

Tang C, Heymach J, Reuben A, Tran H, Welsh J, Liao Z, Tsao A, Swisher SG , Zhang J, Gomez D

2020;6:eabc2487

No, it is not considered a permanent side effect

The inhibition of serine and glycine bidirectional conversion by sertraline prior irradiation reduces the pool of nucleotides, as we previously observed, and concurrent and post-treatment with sertraline might hinder the synthesis of the antioxidant GSH and NADPH production, which exposes cancer cells to the accumulation of endogenous ROS and radiation-induced ROS causing severe oxidative stress [70]