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Bachmann C, Voermans NF, Schr NC, Vissing PL, Fock J

During early liver injury, bone marrow-derived monocytes (BMDMs) extensively infiltrate the liver, differentiating into inflammatory macrophages (predominantly M1), releasing proinflammatory cytokines that trigger hepatic inflammatory responses and activate hepatic stellate cells (HSCs) [1012]

As anti-inflammatory factors, the injection of L-4, IL-10, IL-13, TGF-, or their agonist can play therapeutic roles

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Keep sealed at room temperature for up to 3 months, or refrigerate/freeze for 2+ years of stability