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Thus, we speculate that daily oral semaglutide may not induce the same degree of tachyphylaxis as the weekly subcutaneous semaglutide

doi: 10.1186/s13063-025-08724-x, 157

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If a supplement is taken daily, at gram doses, for months, it deserves the same tracking you would give training load: dose, duration, benefits, side effects, and a clear stop rule