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Use, misuse and abuse of testosterone and other androgens

Molecular patterns of resistance to immune checkpoint blockade in melanoma

Finally, long-term safety follow-up (12 months) is essential to assess risks of chronic Nrf2 activation (e.g., cancer progression) or antioxidant interference with physiological ROS signaling, highlighted by the bardoxolone methyl experience in diabetic kidney disease (Nangaku et al., 2020)