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In colorectal cancer patients, co-treatment with Manuka honey (UMF 15+) and 5-fluorouracil (5-FU) increased intratumoral drug concentration by 62%, attributed to inhibition of efflux transporters such as P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) ( 4.7 Radioprotective effects and DNA repair Honey has shown radioprotective effects based on its ability to enhance DNA repair mechanisms and reduce oxidative damage in irradiated tissues

Other studies have shown how low glutathione levels may be a risk factor for paracetamol hepatotoxicity in alcoholics because a lower dose of paracetamol will be necessary to deplete GSH below the critical threshold concentration where hepatocellular necrosis starts to occur

doi: 10.1016/j.ecoenv.2023.115112 53

Interleukin-10 generation in atopic children following oral Lactobacillus rhamnosus GG

(2020) showed that AS-IV (0.4, 4, 40 M) enhanced the antitumour activity of cisplatin in HCC cells by inhibiting MRP2 expression