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Increased risk of developing sporadic PD after overexposure to manganese, copper, iron and mercury has been studied for decades [69, 70] where it has been suggested that -synuclein, ER stress, and oxidative stress are involved in manganese toxicity in neurons

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Contrary to outdated recommendations that advised restricting protein due to concerns about Hepatic encephalopathy, multiple studies have shown that daily protein intake in the range of 1.21.5 g/kg does not increase the risk of hepatic encephalopathy and may, in fact, improve outcomes such as nitrogen balance, muscle preservation, and quality of life [5, 17,18,19,20]

Pantothenic acid (vitamin B5) has been shown to increase glutathione synthesis by improving cellular energetics [53]

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