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Chronic hyperglycemia and insulin resistance: Increase oxidative stress Deplete glutathione Drive hepatic fat accumulation Elevated GGT frequently precedes the diagnosis of type 2 diabetes

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This variability underscores the lack of standardization inherent in compounded medications

Studies (42, 43) have shown that apigenin has a pro-apoptotic effect in human RA-FLS, and it can induce RA-FLS apoptosis by mediating ROS and oxidative stress activator ERK1/2, and mediate apoptotic cell death by activating the apoptotic effector caspase-3/7

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