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In terms of iron metabolism, studies have found increased iron content in IBD intestinal tissues, higher levels of Fe2+ involved in the Fenton reaction of cellular ferroptosis, and significantly elevated mRNA and protein levels of FTL and FTH1

Dysfunction of the CFTR (cystic fibrosis transmembrane conductance regulator) protein is associated with an increased risk of GI tumors, both in patients with cystic fibrosis and in sporadic GI cancers (353)

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481 NSUN6 facilitates the m 5 C modification of NDRG1 mRNA, thereby enhancing its stability and activating the HR pathway, which in turn augments the radioresistance of cervical cancer

Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas