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Humans (and guinea pigs) lack the enzyme L-gulono--lactone oxidase that catalyses the final step in vitamin C synthesis [2]

Such unregulated injections can cause allergic reactions and even organ damage

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Nevertheless, with advances in synthetic biology and microbiomics, engineered bacteria as live drugs have immeasurable potential in precisely regulating the gutliver axis

With current evidence, the use of dexmedetomidine seems beneficial in a select group of patients in a critical care setting with severe AWS, or in those with delirium, to decrease the need for mechanical ventilation due to high benzodiazepine requirements