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Clinical trials have demonstrated, that upon giving 2 subcutaneous injections 3 months apart, TAK-003 is well-tolerated and immunogenic not only in healthy adults from dengue-nonendemic areas but also in adults and children in dengue-endemic regions [20, 21]

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Overall, it is clear that NAD + fluxes within the cell are complex and dynamic, but the concentrated levels of NAD + in the mitochondria indicate major impacts of the cofactor in this organelle in particular, which will be summarized below