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Risks of Vitamin D3 Deficiency Bone Disorders: Increased risk of osteoporosis, fractures, and bone softening (osteomalacia, rickets)

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In relapsed or refractory myeloma (R/R MM) patients, the CD38 expression levels are relatively high in NK cells, regulatory B cells (Bregs), Tregs and myeloid-derived suppressor cells (MDSCs) compared with CD8 + and CD4 + T cells, indicating that CD38 is involved in providing the immunosuppressive environment for tumor growth [19]

Most importantly, patients reported improvements in body image and the psychosocial impact of lipodystrophy, suggesting a positive effect on quality of life

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