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Low TPP levels notably decrease KGDH activity, thereby decreasing energy production and causing glutamate to accumulate (62), hampering oxidative metabolism and leading to neurodegeneration (63)

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However, continues Brody, The deleterious effects of untreated moderate or severe ADHD far outweigh the relatively mild (if any) adverse effects of (prescription drug) treatment. Methamphetamine in its illegal form is never a suitable alternative to Adderall

doi:10.1016/j.jaad.2024.08.045