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Effect of alcohol abuse and glutathione administration on the circulating levels of glutathione and on antipyrine metabolism in patients with alcoholic liver cirrhosis

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Dr Aaron P Milstone has received speaking and consulting fees from Boehringer Ingelheim, GlaxoSmithKline, Grifols, Insmed, Mylan, and Theravance Biopharma

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The progression from inflammation to fibrosis is primarily mediated by hepatic stellate cell (HSC) activation, which involves two core mechanisms: the Transforming Growth Factor-beta 1 (TGF-1) - Mothers Against Decapentaplegic Homolog 3 (Smad3) pathway and Platelet-Derived Growth Factor (PDGF) -driven epithelial-mesenchymal transition (EMT) 52 , Furthermore, Wnt ligands released by apoptotic bodies promote HSC proliferation through -catenin nuclear translocation 53