glutathione and smoking concentration in BAL cells bronchoalveolar lavage Lung glutathione and oxidative stress:

Front Plant Sci 10:800

Unraveling the potential role of glutathione in multiple forms of cell death in cancer therapy

FIGURE 9 Summary and conclusions: Glutathione and early (premature) inflammaging Chronic inflammatory diseases especially those compromising the lower respiratory system (chronic obstructive pulmonary disease, lower respiratory infections, cystic fibrosis, idiopathic pulmonary fibrosis, acute respiratory distress syndrome), diseases compromising the cardiovascular system (atherosclerosis, ischemic heart disease, stroke, and others), many other systemic inflammatory diseases like diabetes (274, 275)

Many preclinical studies have demonstrated that the expression of key enzymes for GSH synthesis (GCL, SLC7A11, GS) and GSSG reduction-related enzymes (G6PD, NADPH, and GR) is downregulated in myocardium exposed to pathological factors [40, 43,44,45,46,47,48,49,50]

However, research on this topic is inconclusive, and some studies have reported minimal impact of NAC supplementation [62-65]