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The application of tretinoin (ATRA) in melasma lesions in concentration ranges of 0.05%0.1% could effectively decrease skin pigmentation

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Safety Profile & Risks Common Side Effects (usually mild): Injection site pain, irritation, or phlebitis (especially with rapid IV push) Transient nausea, headache, or dizziness Metallic taste during infusion Serious Concerns: Potential liver and kidney strain with high-dose or long-term use Risk of severe allergic reactions (rare) Possible zinc depletion with prolonged use Counterfeit products are extremely common, fake versions may contain unknown contaminants, heavy metals, or incorrect dosing

Recent Progress and Trends in X-ray-Induced Photodynamic Therapy with Low Radiation Doses