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(2020) 370:m2980

It is unknown what mechanisms underlie this PD sex difference, but it is possible that AR45 located in dopaminergic membrane caveolin lipid rafts may be involved, especially as upregulated caveolin expression and lipid rafts have been linked with PD (Hashimoto et al., 2003

In these mice, a significant reduction in the number of c-Fos-positive orexin neurons, hypothalamic prepro-orexin mRNA expression, and orexin-A concentration in the cerebrospinal fluid (CSF) was observed [19], [21]