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Data management & statistical analysis Sample size calculations were based on previous oral wound healing study outcomes for CWE prevalence on day 7 [25], and indicated that a study with 22 participants (11 per group) would have 80% power, at 5% significance level (two-sided), to detect a significant difference between the two groups, assuming a 55% difference in CWE incidence

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Of which, Parkinsons disease (PD) is a progressive neurological ailment characterized by disturbed motor and non-motor functions