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Shibata et al., 1988

The ERK1/2 pathway is a major signaling cascade involved in cell growth, proliferation, and differentiation, including processes vital for angiogenesis

For in vitro applications: dissolve in sterile DMSO for stock solution preparation, then dilute in aqueous buffer (PBS or culture medium) to working concentration

We are presenting it as the clinical pattern we have seen, with the appropriate caveats that clinical observation is subject to selection bias and confounding