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These observations strengthen the evidence that gut microbiota-derived metabolites are closely linked to PD-associated peripheral inflammation

Placebo capsules comprised microcrystalline cellulose (REDWELLS HEALTH LTD, London, UK) combined with 10% (w/w) gum Arabic (CAS 9000-01-5, Willy Benecke, Hamburg, Germany), matching the gum Arabic content of the pomegranate extract, and 1% (w/w) brown food coloring (rainbow dust edible powder color, Cake Decorating Co., UK) to ensure that the pomegranate and placebo capsules were identical in appearance

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2.3 Total phenolic and total flavonoid compounds of NSS, NSO Spectrophotometer, UV/Vis, Jenway, England, was used under environmental conditions: temperature of 20C and 37% rH humidity