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IV and short-duration oral trials METAOD001-004 enrolled smaller groups of healthy or obese men with single doses or 1-week dosing across IV (25-400 mcg/kg) and oral (9-54 mg) routes

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4.5 Mn transporters in neurons and glia Identifying transporters of Mn in neurons and glia is important, as these cells regulate brain Mn homeostasis and are primary targets of Mn neurotoxicity (Pajarillo et al., 2021)