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Oct 1 2016;142(10):959-965

A significant number of patients experience nausea and gastrointestinal discomfort when starting tirzepatide

Sample sizes are modest and risk-of-bias elements vary

doi: 10.1021/mp400547u 440 LiBXuHLiZYaoMXieMShenHet al

An increase in the nuclear translocation of CaMKIV/CREM decreases GPX4, which is accompanied by an increase in intracellular lipid-ROS, eventually leading to neutrophil iron apoptosis (170) ( Figure 3 )