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Researchers who have struggled with tirzepatide losing effectiveness over time might consider whether switching to CagriSema when it becomes available could reignite weight loss through the different amylin-based mechanism

FIGURE 3 Traditional 2D cultures have been the in vitro models used for the longest time in biomedical research and have allowed us to advance our biological knowledge

Ever since, mitochondrial dysfunction has been observed in numerous rodent models of DM, including models of type 1 diabetes mellitus (T1DM) such as streptozotocin (STZ)-diabetic rodents, OVE26 mice, non-obese diabetic (NOD) mice, or in the Akita mouse model, as well as models of T2DM such as ob/ob mice, db/db mice, Zucker (diabetic) fatty rats, Goto Kakizaki rats, and in models of diet-induced obesity [15]

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