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The FAM171A2 gene is a key regulator of progranulin expression and modifies the risk of multiple neurodegenerative diseases

Insulin growth factor-1 (IGF-1) deficiency has been associated with MetS-related pathologies both in-vivo and in-vitro

Markers of lipid and DNA oxidative damage have been detected in several CNS cells, including neurons, axons, myelin, and OLs in early active lesions with the highest levels of expression in cells that morphologically resembled apoptotic OLs [10,11]