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Moreover, serotonin metabolites (5-hydroxyindoleacetic acid) derived from activated platelets and mast cells in the lung can act as ligands to drive eosinophil recruitment via the chemotactic receptor G protein-coupled receptor 35, exacerbating fungal infections (Romero et al., 2015)

Due to their relatively low glycolytic activity, memory CD8 + T cells rely more heavily on exogenous lactate uptake via MCT1, which sustains intracellular lactate levels and promotes histone H3K9 lactylation (H3K9la)