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Human CBS is a complex multidomain enzyme that requires PLP for its activity and binds to a heme group that serves a regulatory role in its enzyme activity

Further studies generated pharmacokinetic profiles of intranasal vascular endothelial growth factor in rats and intranasal allopregnanolone in mice, which measured the highest drug concentrations in the trigeminal nerve, optic nerve and olfactory bulb followed by the cerebrum and hippocampus [79, 80]

Drafting the manuscript for important intellectual content: K.S.H., K.P., W.W., H.S.-D., and S.J.C

Prog Neurobiol (2021) 202:102031

doi: 10.3390/v12101179 185 MordesD