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Published 2015 May 27

It is applied in long-term studies to facilitate continuous observation and allow comparisons across different levels of exposure

Compr Psychiatry

DOI: 10.1016/j.bbamem.2014.02.002 80

They further reported significant improvements compared to the placebo in a measure of functional abilities in activities of daily living (Parkinsons Disease Questionnaire, PDQ-39) and several measures of gastrointestinal comfort, including constipation severity (Wexner score), stool consistency (BSS), number of bowel movements, and constipation-related quality of life (PAC-QOL)