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Moreover, besides the enhanced activity of fibroblasts, which are considered essential for collagen synthesis, tissue repair, and regeneration, there was also a potential rise in mast cell activation

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In the dura mater and other regions supplied by the trigeminal nerve, this results in neurogenic inflammation due to excessive vasodilation, mast cell degranulation, plasma protein extravasation, and the release of inflammatory mediators such as serotonin

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