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doi: 10.1158/1078-0432.CCR-19-4162 74 RosenbergJEHoffman-CensitsJPowlesTvan der HeijdenMSBalarAVNecchiAet al

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[10] [12] These interactions are supported by pharmacokinetic studies, clinical observations, and drug interaction databases

The proposed chain of effects looks like this: NNMT inhibited nicotinamide is no longer inactivated by methylation and becomes available for conversion to NAD+