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The Firmicutes/Bacteroidetes (F/B) ratio is relatively stable in healthy mammals, and the elevation or decline of the ratio frequently indicates the disease state

This electron-rich nature renders thiols potent nucleophiles capable of participating in a wide array of chemical reactions, including nucleophilic substitution, addition, and redox processes

Xu Q, Ohara N, Liu J, et al

In fact, any situation where a mitochondrial source of ROS is detected, either directly such as drugs interacting with subunits of the respiratory chain, or indirectly as in defective mGSH carriers due to lipid changes in the mitochondrial membrane, mGSH could be responsible for cell demise

Aquino, Y