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Growth hormone acts directly on adipocytes to increase lipolysis and on hepatocytes to stimulate gluconeogenesis, but its anabolic and growth-promoting effects are mediated indirectly through the induction of IGF-1

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Studies using cDC models have shown that ROS produced by DCs during antigen cross-presentation help maintain an alkaline environment within the phagosome, which is crucial for preserving the structure of internalized antigens and successfully presenting them via Major Histocompatibility Complex class I (MHC-I) complexes to CD8 + T cells [157]

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