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Methylcobalamin, vitamin B12 preparations containing benzyl alcohol should be avoided in premature neonates because benzyl alcohol has been associated with gasping syndrome, a potentially fatal condition characterized by metabolic acidosis and CNS, respiratory, circulatory, and renal dysfunction

Another study that analyzed data from 7,017 NHANES participants found higher intakes of B6 and folate were each independently associated with a lower risk of severe headaches or migraines, and high intake of both B vitamins was linked to the lowest risk (Tian 2024)

Niacinamide (B) in high pharmacological doses has less pregnancy data

10.1136/bmj.315.7109.629 [DOI] [PMC free article] [PubMed] [Google Scholar] Field E

Clinics often combine these in an IM injection as one component of a broader Weight Management plan