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Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last

In preclinical studies of breast cancer cell lines, inhibition of PAR-1 resulted in a significant reduction in tumor growth and metastatic lesions [135137] (Figure 4)

Therefore, it is essential to design intelligent nano delivery platforms to enhance the bioavailability of Cur and, at the same time, leverage combined therapeutic approaches to better address the complex tumor microenvironment in vivo

3A, Bi@Chi-DEC NPs exhibit nearly uniform and spherical morphologies

Systemic adverse reactions are unlikely from topical administration