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Future research can address these limitations by (1) Considering the complex intercellular functions and regulatory mechanisms to avoid one-sided conclusions

doi: 10.1039/D1RA03640H 472 ChenBHHsiehCHTsaiSYWangCYWangCC

Though pathogenic RFK mutations are rare, animal models have shown that RFK loss results in impaired mitochondrial electron transport, NF-B activation, cognitive decline, and neuroinflammation, highlighting its disease relevance