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In subjects with ACS and CAD, HDL have been reported to have decreased ability to prevent endothelial cell apoptosis likely through decreased activation (phosphorylation) of Bcl-xl and increased activation of Bcl-2, which are anti-apoptotic and pro-apoptotic proteins, respectively (840)

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doi: 10.1097/00002030-199208000-00008 56 VenketaramanVRodgersTLinaresRReillyNSwaminathanSHomDet al

Abstract Redirecting immune cells or therapeutic molecules to cancer targets without harming healthy tissues remains a major challenge