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This type of lesion is directly repaired by a suicide enzyme known as MGMT, which removes the methyl group of the DNA base and transfers it to its cysteine residue

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Furthermore, epigenetic alterations, including DNA methylation, histone modification and non-coding RNAs expression, not only modify Atgs but also affect signaling genes, thus inhibiting or promoting of autophagy (35) (Fig

In addition, SLC25 carriers help regulate the mitochondrial redox state and control the production of reactive oxygen species (ROS), preventing oxidative stress and maintaining cellular health [10]

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