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AOP Development Strategy Context Used to provide background information for AOP reviewers and users that is considered helpful in understanding the biology underlying the AOP and the motivation for its development.The background should NOT provide an overview of the AOP, its KEs or KERs, which are captured in more detail below

A study on substrate binding residues of OsGSTU17 showed that Lys42, Val56, Glu68, and Ser69 are the critical components of G-site, while Pro16, Met17, Asn109, Leu112, Tyr113, Phe116, Trp161, Phe162, and Trp165 are the critical residues of H-site [83]

BMG Labtech)

Severe tubular proteinuria was seen in 35% of exposed workers but in none of the nonexposed workers

State Medicaid programmes are not required to cover weight loss drugs and, as of the first quarter of 2023, only 5 state Medicaid programmes provided unrestricted coverage of liraglutide and semaglutide for this indication and the vast majority of states provided no coverage (Liu & Rome, 2024)