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132 In addition to inflammatory factors, gut barrier disruption promotes the infiltration of eosinophils, M1/M2 macrophages, and fibroblasts, which is accompanied by increased concentrations of IL-13 and TGF-3 in the colon mucosa, supporting the hypothesis that the intestinal barrier is impaired in cancer cachexia

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Fribley AM, Evenchik B, Zeng Q, Park BK, Guan JY, Zhang H, Hale TJ, Soengas MS, Kaufman RJ, Wang CY (2006) Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa

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