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Pathogenesis May arise from fixed macrophages (Kupffer cells) attached to the sinusoidal endothelial cells or from circulating macrophages, unless metastasized from other organs (e.g., skin, uterus)

de Potter, B

Pulmonary fibrosis and oxidative stress model: NF-B / Nrf2 signaling pathway involvement: Redox Biology publication examining oxidative regulation mechanisms: These studies describe GHK-Cu interacting with redox-sensitive signaling networks and inflammatory mediators

Chaban, O

Research conducted by Hui-Hui Xiao and colleagues (156) demonstrated that OVX rats exhibited dyslipidemia, abnormal bile acid metabolism, and insulin resistance, which were correlated with an elevated Firmicutes / Bacteroidetes (F/B) ratio a well-recognized biomarker for steroid deficiency-induced metabolic and skeletal disorders