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Tirzepatide adds GIP receptor activation on top of GLP-1 signaling, engaging additional metabolic control points

In the experiments using Nrf2 inhibitors, cells were pre-treated with 4 M ML385 (MedChemExpress, Cat# HY-100523, NJ, US) for 4 h

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This year has proven transformative for obesity care, driven by science-backed innovation and robust clinical development: Market Performance Novo Nordisk generated $26 billion in combined 2024 revenue from #Ozempic & #Wegovy [ [ Eli Lilly posted Q1 2025 revenues of $3.84 billion for #Mounjaro and $2.31 billion for #Zepbound [ [ Clinical Pipeline 100+ obesity-specific drugs currently in development, backed by 80+ companies [trial.medpath.com] 60+ Phase II/III trials underway, spanning mechanisms like GLP1, dual/triple agonists, amylin analogues, RNA therapies, and metabolic modulators [trial.medpath.com], [novotech-cro.com] Global Reach & Future Trends Trial activity concentrated in North America, Europe & China, with growing efforts in Southeast Asia & Latin America [ #Semaglutide (Wegovy/Ozempic) is expected to go off-patent in key markets by 2026, opening doors for biosimilars and greater patient access [cen.acs.org], [iqvia.com] To view or add a comment, sign in