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Unlike other glutathione peroxidase family members, GPX4 displays a unique catalytic preference for peroxides embedded in biomembrane phospholipids, enabling it to directly eliminate the most destructive lipid peroxidation products located on cellular and organellar membranes, safeguarding membrane stability and function at the source

3) of which eight Cys were nevertheless fully conserved in all investigated model species

In contrast to this antioxidative approach, Vitamin A has also been investigated for its potential role in cellular redifferentiation, contributing to secondary chemoprevention [7]

Nevertheless, therapeutic strategies aimed at enhancing EAAT2 expression are still pursued

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