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Research suggests it can enhance fibroblast activity, promote vascularization, and increase the expression of genes involved in tissue growth and remodeling

The FDA has noted that compounded formulations have not undergone equivalent safety and efficacy testing

Metabolic Regulation

Known risk factors for methotrexate toxicity include dosing errors, metabolic syndrome, hypoalbuminemia, renal dysfunction, lack of folate supplementation, and the concomitant use of drugs that interfere with methotrexate metabolism

Vitamin B12 also helps in the synthesis and formation of methionine, one of the essential amino acids, as an important cofactor