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The observed increase in mitochondrial malate and cytosolic 2-oxoglutarate through elevated SLC25A11 expression aligns with the systemic energetic dysregulation and oxidative stress reported in plasma metabolomic studies in ME/CFS patients

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It was then reviewed for a second time and, after the result was confirmed internally, the sample was disposed of because the laboratory considered it unsafe for staff to handle

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This waning of efficacy is also observed for booster vaccination when Omicron is the dominant circulating variant, with Menegale et al