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Immunotherapy-Associated Hypothyroidism: Comparison of the Pre-Existing With De-Novo Hypothyroidism

Therefore, any research studies using these ingredients should be carefully designed to monitor for potential adverse reactions, and the concentration of these research compounds should be optimized to balance efficacy and safety

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However, these may not be salient features of BH4 supplementation in vivo as they appear to be overshadowed by the positive effect generated by alleviating tumor hypoxia

its deficiency causes the accumulation of low-molecular-weight nitrogen compounds, further impairing plant metabolic processes (Yamamoto et al., 2009)